White Matter Injury in Spinal Cord Ischemia
نویسندگان
چکیده
منابع مشابه
White matter injury in spinal cord ischemia: protection by AMPA/kainate glutamate receptor antagonism.
BACKGROUND AND PURPOSE Spinal cord ischemia is a serious complication of surgery of the aorta. NMDA receptor activation secondary to ischemia-induced release of glutamate is a major mechanism of neuronal death in gray matter. White matter injury after ischemia results in long-tract dysfunction and disability. The AMPA/kainate receptor mechanism has recently been implicated in white matter injur...
متن کاملReevaluation of gray and white matter injury after spinal cord ischemia in rabbits.
BACKGROUND Although gray matter injury has been well characterized, the available data on white matter injury after spinal cord ischemia (SCI) in rabbits are limited. The current study was conducted to investigate the evolution of ischemia induced injury to gray and white matter and to correlate this damage to hind-limb motor function in rabbits subjected to SCI. METHODS Thirty-eight rabbits ...
متن کاملBrain White Matter Impairment in Patients with Spinal Cord Injury
It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics (TBSS) to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fif...
متن کاملA Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio.
BACKGROUND AND PURPOSE T2*-weighted imaging provides sharp contrast between spinal cord GM and WM, allowing their segmentation and cross-sectional area measurement. Injured WM demonstrates T2*WI hyperintensity but requires normalization for quantitative use. We introduce T2*WI WM/GM signal-intensity ratio and compare it against cross-sectional area, the DTI metric fractional anisotropy, and mag...
متن کاملProtective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 2000
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.31.8.1945